MovDisordV3, Main, Exploration, bibRecord, 003050

A unique case of coincidence of early onset Parkinson's disease and multiple sclerosis

Identifieur interne : 003050 ( Main/Exploration ); précédent : 003049; suivant : 003051

A unique case of coincidence of early onset Parkinson's disease and multiple sclerosis

Auteurs : Peter Valkovi [Slovaquie] ; Georgi Krastev [Slovaquie] ; Miroslav Mako [Slovaquie] ; Petra Leitner [Allemagne] ; Thomas Gasser [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-11-15.

RBID : ISTEX:B00A85ACB1B01C636040DFEC696B4003C3D658DF

English descriptors

KwdEn :
- Adult, Age of Onset, Demyelinating Diseases (complications), Demyelinating Diseases (pathology), Humans, Magnetic Resonance Imaging, Male, Multiple Sclerosis (complications), Multiple Sclerosis (pathology), Parkinson Disease (complications), Parkinson Disease (pathology), coincidence, early onset Parkinson's disease, multiple sclerosis.
MESH :
- complications : Demyelinating Diseases, Multiple Sclerosis, Parkinson Disease.
- pathology : Demyelinating Diseases, Multiple Sclerosis, Parkinson Disease.
- Adult, Age of Onset, Humans, Magnetic Resonance Imaging, Male.

Abstract

We report on a patient who developed left arm rest/postural tremor at age 24 and responded well to trihexyphenidyl. One year later spastic paraparesis appeared, and multiple sclerosis was diagnosed on the basis of clinical, radiological, and laboratory evidence. Although paraparesis improved after immunosuppressant therapy, a complete picture of an asymmetric parkinsonian syndrome gradually developed. Excellent response to levodopa, drug‐induced dyskinesias, and DaTSCAN revealing pathology congruent with Parkinson's disease (PD) indicate a coincidental etiopathogenetic relationship of both clinical entities: multiple sclerosis and PD. Genetic analyses focusing on autosomal recessive parkinsonism (parkin, DJ1, and PINK1) were negative. To the best of our knowledge, only 15 cases of parkinsonism in association with multiple sclerosis have been reported, and their relationship has been interpreted to be either causal or coincidental. This is the first report of a coincidence of both entities, in which the parkinsonian syndrome developed first and before age 30. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/B00A85ACB1B01C636040DFEC696B4003C3D658DF/fulltext/pdf

DOI: 10.1002/mds.21642

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">We report on a patient who developed left arm rest/postural tremor at age 24 and responded well to trihexyphenidyl. One year later spastic paraparesis appeared, and multiple sclerosis was diagnosed on the basis of clinical, radiological, and laboratory evidence. Although paraparesis improved after immunosuppressant therapy, a complete picture of an asymmetric parkinsonian syndrome gradually developed. Excellent response to levodopa, drug‐induced dyskinesias, and DaTSCAN revealing pathology congruent with Parkinson's disease (PD) indicate a coincidental etiopathogenetic relationship of both clinical entities: multiple sclerosis and PD. Genetic analyses focusing on autosomal recessive parkinsonism (parkin, DJ1, and PINK1) were negative. To the best of our knowledge, only 15 cases of parkinsonism in association with multiple sclerosis have been reported, and their relationship has been interpreted to be either causal or coincidental. This is the first report of a coincidence of both entities, in which the parkinsonian syndrome developed first and before age 30. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

A unique case of coincidence of early onset Parkinson's disease and multiple sclerosis

A unique case of coincidence of early onset Parkinson's disease and multiple sclerosis

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.